Researcher |Research Overview
The Randolph Lab studies the immunobiology of critical illness in children with a focus on life-threatening and fatal infections and acute lung injury. Our long-term goal is to identify new diagnostic tests and therapies that could restore health more rapidly and decrease morbidity and mortality. Our laboratory focuses on clinical-translational research in the areas of the immune response of pediatric patients with acute respiratory distress syndrome and/or overwhelming sepsis, and on identifying genomic pathways that influence disease susceptibility and/or severity. Dr. Randolph founded the Pediatric Acute Lung Injury and Sepsis Investigator’s Network in 2002 (https://www.palisi.org/) and was the Chair for its first 8 years. PALISI is a voluntary clinical-translational research consortium that now includes 80 pediatric intensive care units across the U.S. and Canada.
PALISI网络已在重病的儿童中发表了175多种临床和翻译研究，其中包括在NEJM和JAMA发表的多个地标随机临床试验。2008年，伦道夫博士在帕利西（Palisi）内开发了小儿重症监护流感（PICFLU）研究小组，并获得了美国疾病控制和预防公共卫生基因组学中心的赠款，以识别流感病毒易感性和严重性的基因。在2009年H1N1流感大流行期间，收到了额外的资金来增加入学率。2010年，美国国家卫生研究院国家过敏和传染病研究所资助了PICFLU，研究了儿童和年轻人对威胁生命和致命的流感感染的遗传流行病学和免疫反应。PICFLU集团已从多个来源获得超过1300万美元患有多器官功能障碍综合征和/或免疫分析的人。伦道夫博士还在与流感和ARDS基金会作斗争的家庭医疗咨询委员会上。有关PICFLU网络的更多信息，请访问我们的网站http://picflu.org.
Researcher |Research Background
Dr. Randolph graduated from Stanford Medical School and completed her pediatrics residency and critical care fellowship at the University of California, San Francisco. At UCSF she completed research fellowships at the Institute for Health Policy Studies and at the Cardiovascular Research Institute. She has a Master of Science degree in biomedical informatics from the University of Utah. She has designed and implemented clinical decision support tools for guiding care of mechanically ventilated patients and worked with trainees to use large datasets to answer important clinical questions about clinical outcomes and use of therapies in children. Dr. Randolph also performs clinical research to advance patient safety and quality in the Medical Surgical Intensive Care Unit at Boston Children’s Hospital with a focus on optimizing methods of liberating children from mechanical ventilator support and improving outcomes of children who become critically ill after stem cell transplantation.
选定的出版物
- Randolph AG, Wypij D, Venkataraman ST, Hanson JH, Gedeit RG, Meert K, Luckett PM, Forbes P, Lilley M, Thompson J, Cheifetz IM, Hibberd P, Wetzel R, Cox PN, Arnold JH. Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children - A randomized controlled trial. Journal of the American Medical Association 2002; 288: 2561-88.
- Randolph AG, Gonzales CA, Cortellini L, Yeh TS. Growth of pediatric intensive care units in the United States from 1995 to 2001. Journal of Pediatrics 2004; 144: 792-98
- Guidelines for the prevention of intravascular catheter-related infections - art. no. e51. Pediatrics 2002; 110: E51.
- Randolph AG, Lange C, Silverman EK, Lazarus R, Silverman ES, Raby B, Brown A, Ozonoff A, Richter B, Weiss ST. IL12B gene is associated with asthma. Am J Hum Genet 2004:75;709-715.