生物统计学研究设计|Boston Children's Hospital

生物统计学研究设计|Overview

使命

吟游诗中心的任务是在波士顿儿童医院的研究研究和分析研究方面促进卓越。欧宝彩票平台ICCTR BARD中心通过与波士顿儿童研究人员的合作关系提供生物统计学和方法论专业知识以及科学领导。该中心还提供各个领域的教育产品。

Our group includes PhD and masters-level staff with experience in the design and analysis of a wide range of research studies, including pre-clinical experiments, observational and randomized studies, health econometrics and survey research, qualitative evaluations, and high dimensional functional neuroimaging studies.

BARD services include:

Full biostatistical project support, tailored to your study and resources
与我们的教师研究人员的长期合作
Study design and grant preparation
Short term consultations with our staff

有关更多信息，请联系：

Dr. Edie Weller, Center Director
Dr. Michael Monuteaux, Center Assistant Director

The ICCTR BARD Center congratulates the following members on their promotions:

Kim Greco, MPH, on her promotion to Biostatistician II
Carly Milliren, MPH, on her promotion to Biostatistician IV
Bo Zhang博士，晋升为神经病学副教授

Congratulations Kim, Carly and Bo!

BARD Services

The Biostatistics and Research Design (BARD) Center faculty and staff can collaborate with investigators on:

Protocol development/Grant preparation

We can ensure that the study objectives, specific aims, and endpoints are well defined, measurable and feasible and advise on appropriate design and methods. Members can write sections related to research aims, data collection and data management methods, registration and randomization, sample size and power, statistical analysis methods and interim monitoring.

Study Design and Planning

We provide advice on the most efficient, valid, and feasible study design (eg., cohort, case control, prospective, retrospective, cross sectional, randomized clinical trial, etc.) as well as advice on:

appropriate selection of the sample from the target population
choice of control group(s)
strategies for recruitment and retention
data collection methods
数据库设计

In addition, we provide guidance on design issues that are unique to the following methodologies:

qualitative studies (use of focus groups, semi-structured or cognitive interviews)
survey research, including instrument creation/validation and sampling and data collection methods (e.g., in-person or telephone interviews, mail surveys, web surveys)
health econometrics (e.g., cost impact, cost-effectiveness, cost-benefit evaluations)

Randomization

We generate randomization schemes and assignments for single- and double-blind studies. Members work in conjunction with the Research Pharmacy for the implementation of investigator-initiated randomized trials.

Data analysis

We analyze study data, provide interpretation of statistical analysis results, including interpretation of previously published results as well as results of ongoing analyses. This includes guidance on and development of:

statistical graphics and tabular displays of data
interim or final data analyses
data and safety monitoring board reports

In addition, we provide support for analysis issues that are unique to:

qualitative studies (advice on how to analyze qualitative data including transcribing and coding of focus groups and interviews)
survey research (data analysis from complex survey design, including the use of post-survey adjustments and post-stratification weights)
econometrics research (advice on cost impact, cost-effectiveness, cost-benefit analysis and other types of economic evaluations)

手稿准备

We can contribute to the writing of manuscripts for submission to peer-reviewed scientific journals and prepare abstracts and presentations for scientific meetings.

Education

The Biostatistics and Research Design (BARD) Center offers educational opportunities for Boston Children's researchers on statistical design and analysis considerations for research studies. We also offer workshops on the use of statistical packages for data management and reporting. The objective of the BARD Educational Program is to impart a practical, conceptual understanding of the content we teach. Specifically, in each course we strive to achieve the following learning objectives:

an understanding of the purpose/intent of the method
an understanding of when/under what circumstances the method is applicable
在上下文中解释方法结果的能力
an ability to critically evaluate the scientific literature where the method is used
在适当的情况下，可以在生物统计学家的指导下使用该方法的能力

Spring 2022 course schedule

查看2022春季吟游诗人课程时间表, and select a course to register.

Educational program offerings

The following table provides a description of the BARD Educational Offerings. Please注册课程。我们还鼓励研究人员还探索哈佛催化剂的教育机会。接触icctr-education@childrens.harvard.eduwith any questions.

Course Title	Course Description	Supporting Materials
General
How to Work with a Biostatistician	工作的基本原则with a biostatistician.
Design Series
Case Series and Case-Control Studies	Design and implementation of case series and case-control studies in the context of specific biomedical examples.
Clinical Trials	In this course, an introduction to clinical trials will be offered in 3 parts dedicated to discussing the statistical aspects of phase I, II and III trials.	Session 1/Phase I Trials 会议2/II期试验会议3/III期试验
Cross-Sectional and Cohort Studies	使用儿科临床研究绘制的示例的横断面和队列研究设计的实践概述	video & slides
Design Makes a Difference: Choosing the Right Design for Your Research Question	Concepts essential for writing a grant proposal/protocol; communicating results; and appraising others’ work.	video & slides
Power and How to Get It: Sample Size and Detectable Effects	Justifying the design and sample size for grants/protocols; assessing power and communicating key issues.	video & slides
Survey Research: Design, Implementation and Analysis	Design, implementation, and analysis of survey research in pediatrics.	Session 1 and 2:video & slides Session 3:video & slides Session 4:video & slides
Analysis Series
Data Visualization and Basic Statistical Testing	Basic principles of biostatistics. Related course -Data Management and Reporting in SPSS.	Session 1:video & slides Session 2:video & slides Session 3:video & slides Session 4:video & slides
Linear Regression	Concepts and examples of linear regression analysis.	video & slides
Logistic Regression	逻辑回归分析的示例和解释。	video & slides
Longitudinal Analysis	Examples and interpretation of longitudinal analysis.	video&slides
Survival Analysis	Survival analysis - what is it and why is it different?	Session 1:video & slides Session 2:video & slides
Special Topics
Data management and reporting in SPSS	Introduction to the statistical software package SPSS. Related course- Data Visualization and Basic Statistical Testing.	Session 1:video & slides Session 2:video & slides Session 3:video & slides Session 4:video & slides
Economic Evaluation Methods	卫生保健干预措施的经济评估原则；经济成果的测量/分析。	video & slides
Inter-rater Reliability Studies	Analysis of studies with multiple raters to determine reliability.	video & slides
Introduction to STATA	Introduction to the statistical software package STATA and how it can be used in clinical research	video
定性方法	Introduction to qualitative research for use in pediatrics research.	video & slides
统计考虑s for Laboratory Researchers	Design and analysis issues relevant for pre-clinical research (for example, cell lines, in-vitro, in-vivo)
Survey Validation Methodology	Item development, instrument and scale construction and the psychometric properties of a survey instrument.	video & slides
The Fuss About P Values	P-values and hypothesis testing, the go-to technique for statistical inference in all branches of science for nearly a century, have nonetheless been under constant attack ever since they were introduced. The controversy is as hot as ever today. This single-session course will review the issues, survey alternatives, and provide guidance for everyday practice.	video & slides

A man faces a dark blue board and writes math equations in white marker.

Frequently asked questions

Who can request help?

Any faculty or trainee at BCH is eligible to request our help. Clinical, preclinical, or translation research studies are all eligible.

When should I consult with a biostatistician?

As early in the planning stages of your study as possible!

How can I access services?

Use the following flow chart to determine how to access services or fill out an在线支持请求。

How does 'funded support' work?

BARD Access Flowchart.

"Funded support" is required if the investigator needs more help than a one-hour consult can provide.
A BARD Center team member and Investigator determine the number of hours/effort needed.
Budget and scope of work are created and approved by ICCTR and Investigator.

Please note:

Rates vary according to expertise and experience.
Funding is not required if the work is for an extramural grant application that budgets support for the BARD staff member (as co-investigator, or key personnel).
Trainees (e.g. residents and fellows) with research scholarship requirements can receive 20 hours of support for a discounted rate if BARD Center Members have availability.

How to do I prepare for a consult with a BARD Center member?

Have your study aims/hypotheses finalized.
If possible, explore funding resources in case you require additional support beyond the consult.
Consider whether the degree of collaboration you require with the BARD Center member may entail authorship on the resulting academic product.