Pathology

Chiarle lab

The Chiarle Laboratory is interested in genetic mechanisms and therapy of cancers. By exploiting genome-wide approaches, we aim at understanding the general principles that govern the formation of chromosomal translocations in cancers and their therapeutic vulnerabilities. In translational efforts, we are developing innovative immunotherapies for tumors, including a vaccine to elicit strong and specific immune responses against tumors that express ALK and ALK-specific chimeric antigen receptor (CAR) T cells.

Fleming lab

The Fleming Laboratory is interested in three general areas: 1) understanding how mammals acquire and utilize iron for the purpose of heme synthesis and erythropoiesis, 2) the genetics of rare inherited blood diseases, including genetic iron overload and iron deficiency, congenital anemias (particularly congenital sideroblastic anemia) and other cytopenias, as well as bone marrow failure disorders, and 3) the role of the ubiquitin-proteasome system (UPS) in modifying the erythroid proteome during terminal erythropoiesis. To investigate these areas, we take two general approaches. First we using next generation sequencing techniques to identify the genes underlying mouse and human disease phenotypes. Second, using targeted mutagenesis in the mouse, we are studying proteins implicated in systemic, intracellular and erythroid iron homeostasis, and the UPS.

Haynes lab

The Haynes Laboratory engages in basic and translational science to better understand biological vulnerabilities that contribute to the Sudden Infant Death Syndrome (SIDS) and to elucidate means by which we can ultimately prevent this death from occurring. We focus on two overarching questions: (1) what are the pathogenic mechanisms underlying SIDS and; (2) can we utilize biomarkers of these mechanisms to identify living infants most at risk for SIDS? Through neurobiologic, genomic, proteomic, metabolomic, and physiologic approaches, our research includes unique collaborations with clinicians developing translational approaches to Sudden and Unexpected Death in Pediatrics and scientists studying animal models related to SIDS.

Kanarek lab

The Kanarek Laboratory is interested in folate metabolism. It is surprising that this essential vitamin, so famous for its key role in development, hematopoiesis and cancer progression, is still a mystery when it comes to its cellular and whole-body sensing and homeostasis.

The Kanarek lab applies genetic perturbations, biochemical assays, molecular biology, functional genomic screens, and metabolite profiling by mass spectrometry in cell-culture systems andin vivoto study basic folate biology including folate metabolism, folate-related signal transduction, the oncogenic role of folate and folate homeostasis in normal physiology and pathological conditions.

Lehtinen lab

Lehtinen实验室是如何着迷choroid plexus – cerebrospinal fluid (CSF) system instructs brain development and lifelong heath. Recent work in the lab has focused on investigating how the CSF proteome is regulated by the choroid plexus, a tissue located in each ventricle in the brain. We have produced a cellular and spatial map of the choroid plexus using sequencing approaches. A major goal is to adapt emerging imaging technologies in order to access and control CSF productionin vivo. With this toolkit, we are addressing exciting questions about normal brain development, and exploring disease mechanisms underlying neurodevelopmental as well as age-associated neurologic conditions including hydrocephalus, mental health, and cancer.

Steen lab

The Steen Laboratory is developing and applying computational methods and high throughput proteomics pipelines for the time- and cost-efficient analysis of a wide range of primary human specimens ranging from tissue to urine, CSF and plasma/serum with the ultimate goal to identify new biomarkers and/or drug targets. The areas of interest range from neurodegeneration,pancreatic diseasesandsystems immunology. The Steen Laboratory is equipped with its own suite of state-of-the-art high resolution/high accuracy mass spectrometers as well as a triple quadrupole instrument.