Research & Innovation |Overview
Given their rarity, there is limited research onheart tumors, but over the years, theBenderson Family Heart Center teamhas made clinical research a priority. Their focus has been in three primary areas.
Heart tumor diagnostics
The team has developed methodology to identify tumor type by MRI in conjunction with echocardiography.
- Kiaffas MG, Powell AJ, Geva T.Magnetic resonance imaging evaluation of cardiac tumor characteristics in infants and children.Am J Cardiol 2002;89:1229-1233.
- Mackie AS, Kozakewich HPW, Geva T, Perez-Atayde AR, Mulliken JB.Vascular tumors of the heart in infants and children: Case series and review of the literature.Ped Cardiol 2005;26:344-349.
- Beroukhim RS, Prakash A, Valsangiacomo Buechel ER, Cava JR, Dorfman AL, Festa P, Hlavacek AM, Johnson TR, Keller MS, Krishnamurthy R, Misra N, Moniotte S, Parks J, Powell AJ, Soriano BD, Srichai MB, Yoo SJ, Zhou J, Geva T.Characterization of cardiac tumors in children by cardiovascular magnetic resonance imaging: a multicenter experience.J Am Coll Cardiol 2011;58:1044-1054.
- Beroukhim RS, Geva T. Primary and secondary cardiac tumors. In: da Cruz EM, Ivy D, and Juggers J (eds.). Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care. London: Springer-Verlag 2014;2275-2295
Tumor-associated arrhythmias
Potentially life-threateningarrhythmiasoften complicate cardiac tumors.Our team has extensive experience with management of atrial and ventricular arrhythmias in these patients and has published on treatment strategies in patients with rhabdomyomas and fibromas.
Miyake CY, del Nido PJ, Alexander ME, Cecchin F, Berul CI, Triedman JK, Geva T, Walsh EP.Cardiac Tumors and Associated Arrhythmias in Pediatric Patients, With Observations on Surgical Therapy for Ventricular TachycardiaJ Am Coll Cardiol 2011;58:1903-1909
Chrystalle Katte Carreon, Stephen P. Sanders, Antonio R. Perez-Atayde, Pedro J. del Nido, Edward P. Walsh, Tal Geva, Mark E. Alexander.小儿心脏纤维瘤中的心肌舌头：心室心动过速和心脏骤停的合理底物. JACC Clin Electrophysiol. 2019 May;5(5):563-575.
Surgical management and techniques
Surgery is the most comprehensive and contemporary approach in carefully selected patients with pediatric cardiac tumors. However, the management strategy and, in particular, the surgical approach for ventricular fibromas can pose a challenge. The large tumor size in relationship to the ventricular chambers and encroachment on vital adjacent structures has often been considered a limiting factor.
心脏肿瘤小组已安全地管理了大型心室纤维瘤，总切除术，从而消除了威胁生命的心律不齐的风险，并以极好的临床结果为单位。我们不建议对纤维瘤治疗的儿童进行心脏移植。
Nathan M, Fabozzo A, Geva T, Walsh E, del Nido JP.Successful surgical management of ventricular fibromas in childrenJ Thorac Cardiovasc Surg 2014;148:2602-8