高级肠道康复中心（CAIR）|正在进行的研究项目

在CAIR，我们正在不断努力改善短肠综合征and related concerns. Some of our current and recent research projects include:

短肠综合征的标记

Our researchers are measuring blood and stool markers of intestinal adaptation in children with short bowel syndrome over the course of a year. They will investigate how these markers relate to growth and weaning off of parenteral nutrition.

开发维生素D缺乏症的治疗算法

在研究实验室趋势之后，我们已经修改了维生素D缺乏症的治疗计划，并根据这种维生素的年龄和水平进行了更改。我们将收集数据，以确定我们新建议在治疗维生素D缺乏方面的有效性。

Copper status in infants with prolonged dependence on parenteral nutrition

Prospective data was collected on a group of children with intestinal failure and dependence on肠胃外营养。Our researchers are now analyzing their blood levels of copper and various potential risk factors for copper deficiency to help optimize prevention and treatment of this problem in pediatric short bowel syndrome.

评估身体成分

The Bodpod (also called air displacement plethysmography) is a safe, quick, non-invasive technique that measures both the muscle mass and fat mass in children. Since routine measures such as weight gain may not be sensitive enough to assess the actual gain of muscle mass, the Bodpod may allow for a better assessment of a child’s body composition.

肝纤维化的非侵入性评估

Vibration-controlled transient elastography, also called FibroScan®, is a new diagnostic tool to assess liver fibrosis in pediatric intestinal failure patients with associated liver disease. FibroScan results for our CAIR patients have shown that the diagnostic tool is successful and a valid method for non-invasive monitoring of liver injury in this population.

Methionine breath test

监测肝功能仅限于与肠道衰竭相关肝病患者的常规血液检查或肝活检。稳定同位素的代谢L [1-13C]蛋氨酸已显示出在肝脏中仅发生，并且是安全，无创和有效的肝脏线粒体功能的有效度量。CAIR团队目前正在评估串行呼吸测试的可行性和相关性，以测量随着时间的推移肝功能的变化。

Distraction enterogenesis

小肠的剩余长度是预测肠综合征短的患者是否能够成功地解脱出肠胃外营养的最重要因素。已经描述了通过机械拉伸延长肠道的技术，CAIR团队正在进行的研究中，采用腔外拉伸以拉长小肠并刺激组织生长。

超短肠综合征的长期结局

Our CAIR team recently reviewed long-term outcomes in patients with a history of midgut volvulus leading to ultra-short bowel syndrome. We have found that midgut volvulus with extensive bowel loss is associated with favorable long-term survival, and that weaning off parenteral nutrition is feasible with intestinal rehabilitation.

长期结局

成千上万的儿童有短肠syndrome; however, with the advent of parenteral nutrition and advances in intestinal rehabilitation, many are now surviving to adulthood. The primary aim of this study is to observe long-term medical and surgical outcomes of adolescents nearing adulthood as we work towards transition of care for these patients.

Quality of life

The CAIR team is actively enrolling patients in a study to learn more about the quality of life experienced by children with intestinal failure. This is a collaborative study being conducted by intestinal rehabilitation centers throughout the country. It is being co-led byBiren Modi博士at Boston Children’s and Dr. Patrick Javid at Seattle Children’s Hospital. Your family may be approached to inquire about participation in this study at a future appointment. If you have questions or want to discuss participation please feel free to联系我们的办公室了解更多信息。

Relizorb的影响

Led by马克·普德（Mark Puder），医学博士这项研究的主要目的是确定RELIZORB是否与肠胃外营养的卡路里减少有关。在研究结束时，我们还将衡量儿童体重的变化。

To determine if your child is eligible for this study, please contactrelizorbstudy@childrens.harvard.edu。

及时推注（败血症中平衡与正常盐水液的务实儿科试验）

这项临床研究将比较两种常用的小儿脓毒症静脉治疗，以查看一种是否比另一种更有效，更安全。所有在波士顿儿童医院急诊室与败血症的儿童都有资格参加这项研究。欧宝彩票平台有关更多信息或与学习团队联系，请访问试用网站。

STARS

The CAIR team is about to begin an exciting new study called STARS in adults ages 18 and older with short bowel syndrome/intestinal failure (SBS-IF). STARS is a clinical trial looking at the efficacy and safety of weekly subcutaneous injections ofapraglutide（GLP-2类似物）在减少肠胃外营养（PN）依赖性方面。它是一项国际，多中心，双盲，随机，安慰剂对照试验。该试验包括筛查阶段，48周的治疗阶段和安全随访阶段。成功筛选后，试用参与者将每周获得一次Apraglutide或安慰剂。这项研究由Vectivbio AG赞助。

• 波士顿儿童网站首席研究员：亚历山德拉·凯里（Alexandra Carey）博士
• Boston Children’s co-investigator:克里斯托弗·杜根（Christopher Duggan）博士