Laboratories and Centers|Laboratories and Centers

TheBerde Laboratoryresearch concerns pediatric anesthesiology and the management of acute and chronic pain in children. Clinical research areas include pharmacology of analgesics and local anesthetics, neurophysiology of general anesthesia in children, clinical outcomes of treatment of neuropathic pain and cancer pain in children, and functional brain imaging of children with neuropathic pain.

TheBiobehavioral Pediatric Pain Laboratory是共同的Dr. Laura Simons andDr. Christine Siebergwithin theDepartment of Psychiatry and Behavioral Sciences, and theDepartment of Anesthesiology, Critical Care and Pain Medicine在波士顿儿童的人们tal. Their research projects focus on biological, neurological, cognitive, affective, and social risk and resiliency factors of the pain experience. Projects include animal model, brain imaging, longitudinal clinical cohort, and treatment interventions studies.

TheBrain and Eye Pain Imaging Labinvestigates nociceptive processing in the human central nervous system, particularly as it relates to oculofacial pain and related disorders. We combine functional and structural neuroimaging techniques, including functional MRI and corneal microscopy, to address translational topics related to pain in patients and volunteers.

TheCenter for Analysis and Research in Peri-Procedural Outcomes (CARPPO)was established to improve the perioperative and sedation experiences for youth and families undergoing medical procedures requiring anesthesia or sedation throughout the hospital.

Center for Pain and the Brain (P.A.I.N. Research Group)是共同的David Borsook, MD, PhD, and Lino Becerra, PhD. Their research focuses on the discovery of novel pain pathways (Systems Biology), mapping the CNS response/s in neuropathic pain and analgesics (Biotherapeutics), developing novel high-throughput methods for evaluating analgesics (Predictive Medicine), and incorporating results from animal research into human applications (Translational Medicine). The vision of their program is to produce methods for objective evaluation of chronic pain and methods for evaluation of therapeutics.

TheCommons Laboratoryis led byKathryn Commons, PhD. Her research involves a combination of neuroanatomy and behavioral pharmacology in mouse models to study the brain at the systems level. The overall goal is to understand how serotonin has the ability to influence every behavioral output.

Dusica Bajic, MD, PhD, created a key program using infant animal models to determine how morphine acts in the developing brain. For her work in this area, she has received funding from the prestigiousFoundation for Anesthesia Education and Research(FAER).

TheKohane Laboratoryis led byDaniel Kohane, MD, PhD. His research focuses on drug delivery, biomaterials in general and nanomedicine in particular. This has included polymeric and other micro-particles and nanoparticles, liposomes, hydrogels, targeted particles, macroscopic devices, and combinations of the above.

ThePK Laboratorywas created to provide clinicians and researchers with a core competence in Quantitative Clinical Pharmacology and Pharmacometrics (QCPP). “Pharmacometrics is the science which deals with quantitative description of disease, drug effects and variability" (ref.American College of Clinical Pharmacology).

TheYuki Laboratorystudies the pathophysiology of sepsis and tumor recurrence/metastasis.