Hans Oettgen, MD, PhD

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1. 免疫变化超出Th2 pathways during rapid multifood immunotherapy enabled with omalizumab. Allergy. 2021 09; 76(9):2809-2826.View abstract
2. Mast Cells as Regulators of Adaptive Immune Responses in Food Allergy. Yale J Biol Med. 2020 12; 93(5):711-718.View abstract
3. 调节性T细胞衍生的TGF-ß1控制多个控制过敏和自身免疫性的检查点。免疫。2020 Dec 15; 53(6):1331-1332.View abstract
4. IgE and IgG Antibodies as Regulators of Mast Cell and Basophil Functions in Food Allergy. Front Immunol. 2020; 11:603050.View abstract
5. 通过omalizumab预防高风险儿童（公园）的哮喘：设计，理由，方法，经验教训和适应。当代临床试验。2021 01;100：106228。View abstract
6. IgE and mast cells: The endogenous adjuvant. Adv Immunol. 2020; 148:93-153.View abstract
7. 调节性T细胞衍生的TGF-ß1控制多个控制过敏和自身免疫性的检查点。免疫。2020 12 15;53（6）：1202-1214.e6。View abstract
8. 奥美拉唑抑制了小鼠摄入过敏原诱导的IgE介导的肥大细胞激活和过敏性炎症。J过敏临床免疫。2020 10;146（4）：884-893.e5。View abstract
9. 人FC？ri的可溶性同工型是IgE介导的肥大细胞反应的内源性抑制剂。过敏。2019 02;74（2）：236-245。View abstract
10. Immunoglobulin E blockade during food allergen ingestion enhances the induction of inhibitory immunoglobulin G antibodies. Ann Allergy Asthma Immunol. 2019 02; 122(2):213-215.View abstract
11. Tissue-Specific Expression of the Low-Affinity IgG Receptor, Fc?RIIb, on Human Mast Cells. Front Immunol. 2018; 9:1244.View abstract
12. Importance of basophils in eosinophilic asthma: the murine counterpart. J Biol Regul Homeost Agents. 2018 Mar-Apr; 32(2):335-339.View abstract
13. IgE promotes type 2 innate lymphoid cells in murine food allergy. Clin Exp Allergy. 2018 03; 48(3):288-296.View abstract
14. Food allergy. Nat Rev Dis Primers. 2018 01 04; 4:17098.View abstract
15. 支柱文章：X连锁的淋巴增生性疾病基因产物SAP调节通过共受体大满贯诱导的信号。自然。1998. 395：462-469。J免疫。2017 09 01;199（5）：1534-1541。View abstract
16. Allergen-specific IgG antibody signaling through Fc?RIIb promotes food tolerance. J Allergy Clin Immunol. 2018 01; 141(1):189-201.e3.View abstract
17. A humanized mouse model of anaphylactic peanut allergy. J Allergy Clin Immunol. 2017 01; 139(1):314-322.e9.View abstract
18. Fifty years later: Emerging functions of IgE antibodies in host defense, immune regulation, and allergic diseases. J Allergy Clin Immunol. 2016 06; 137(6):1631-1645.View abstract
19. IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function. J Allergy Clin Immunol. 2016 09; 138(3):801-811.e9.View abstract
20. 食物过敏发病机理中的IgE受体信号传导。Curr Opin Immunol。2015年10月;36：109-14。View abstract
21. IgE and Mast Cells: The Endogenous Adjuvant. Adv Immunol. 2015; 127:203-56.View abstract
22. 调节性T细胞对Th2细胞样谱系的重编程会损害口腔耐受性并促进食物过敏。免疫。2015年3月17日;42（3）：512-23。View abstract
23. 多克隆IgE诱导肥大细胞存活和细胞因子产生。过敏反应。2009;58（3）：411-419。View abstract
24. Anti-IgE therapy: clinical utility and mechanistic insights. Curr Top Microbiol Immunol. 2015; 388:39-61.View abstract
25. 口服免疫疗法诱导通过FC RIIB作用的IgG抗体抑制IgE介导的过敏性。J过敏临床免疫。2014年12月;134（6）：1310-1317.e6。View abstract
26. Immunoglobulin E signal inhibition during allergen ingestion leads to reversal of established food allergy and induction of regulatory T cells. Immunity. 2014 Jul 17; 41(1):141-51.View abstract
27. Food allergy: Insights into etiology, prevention, and treatment provided by murine models. J Allergy Clin Immunol. 2014 Feb; 133(2):309-17.View abstract
28. Basophils are rapidly mobilized following initial aeroallergen encounter in naïve mice and provide a priming source of IL-4 in adaptive immune responses. J Biol Regul Homeost Agents. 2014 Jan-Mar; 28(1):91-103.View abstract
29. IL-10 suppresses IL-17-mediated dermal inflammation and reduces the systemic burden of Vaccinia virus in a mouse model of eczema vaccinatum. Clin Immunol. 2014 Feb; 150(2):153-60.View abstract
30. An IgE receptor mimetic peptide (PepE) protects mice from IgE mediated anaphylaxis. Mol Biosyst. 2013 Nov; 9(11):2853-9.View abstract
31. 免疫球蛋白E在宿主防御蜜蜂毒液中的有益作用。免疫。2013年11月14日;39（5）：963-75。View abstract
32. 表皮敏化导致IgE依赖性肠道肥大细胞的扩张和食物诱导的过敏反应。J过敏临床免疫。2013年2月;131（2）：451-60.E1-6。View abstract
33. 与实验性食物过敏相关的微生物群特征可促进过敏敏化和过敏反应。J过敏临床免疫。2013年1月;131（1）：201-12。View abstract
34. Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy. Mucosal Immunol. 2013 Jul; 6(4):740-50.View abstract
35. IL-21 is the primary common ? chain-binding cytokine required for human B-cell differentiation in vivo. Blood. 2011 Dec 22; 118(26):6824-35.View abstract
36. 除了直接过敏之外：IgE抗体在免疫稳态和过敏性疾病中的作用不断发展。Immunol Rev. 2011年7月；242（1）：128-43。View abstract
37. Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice. J Allergy Clin Immunol. 2011 Jun; 127(6):1552-61.e1.View abstract
38. High-affinity IgE receptors on dendritic cells exacerbate Th2-dependent inflammation. J Immunol. 2011 Jul 01; 187(1):164-71.View abstract
39. Mast cells and tumour necrosis factor alpha (TNF-a): partners in crime in asthma pathogenesis. Clin Immunol. 2011 Jul; 140(1):1-2.View abstract
40. IgE-mediated systemic anaphylaxis and impaired tolerance to food antigens in mice with enhanced IL-4 receptor signaling. J Allergy Clin Immunol. 2011 Mar; 127(3):795-805.e1-6.View abstract
41. Anti-IgE in the treatment of allergic disorders in pediatrics. Curr Opin Pediatr. 2010 Dec; 22(6):758-64.View abstract
42. Immune response to varicella vaccine in children with atopic dermatitis compared with nonatopic controls. J Allergy Clin Immunol. 2010 Dec; 126(6):1306-7.e2.View abstract
43. Skin inflammation arising from cutaneous regulatory T cell deficiency leads to impaired viral immune responses. J Immunol. 2010 Jul 15; 185(2):1295-302.View abstract
44. IL-4受体α链免疫受体抑制基序对过敏反应的体内调节。J过敏临床免疫。2010年5月;125（5）：1128-1136.e8。View abstract
45. Adaptive immunity. J Allergy Clin Immunol. 2010 Feb; 125(2 Suppl 2):S33-40.View abstract
46. Exaggerated IL-17 response to epicutaneous sensitization mediates airway inflammation in the absence of IL-4 and IL-13. J Allergy Clin Immunol. 2009 Oct; 124(4):761-70.e1.View abstract
47. Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma. J Exp Med. 2009 Sep 28; 206(10):2191-204.View abstract
48. Vaccinia virus inoculation in sites of allergic skin inflammation elicits a vigorous cutaneous IL-17 response. Proc Natl Acad Sci U S A. 2009 Sep 01; 106(35):14954-9.View abstract
49. Polyclonal IgE induces mast cell survival and cytokine production. Allergol Int. 2009 Sep; 58(3):411-9.View abstract
50. 林恩激酶控制嗜碱细胞GATA-3转录factor expression and induction of Th2 cell differentiation. Immunity. 2009 Apr 17; 30(4):533-43.View abstract
51. Novel presentation of Omenn syndrome in association with aniridia. J Allergy Clin Immunol. 2009 Apr; 123(4):966-9.View abstract
52. Toll-like receptor 2 is important for the T(H)1 response to cutaneous sensitization. J Allergy Clin Immunol. 2009 Apr; 123(4):875-82.e1.View abstract
53. IgE influences the number and function of mature mast cells, but not progenitor recruitment in allergic pulmonary inflammation. J Immunol. 2009 Feb 15; 182(4):2416-24.View abstract
54. IL-21R is essential for epicutaneous sensitization and allergic skin inflammation in humans and mice. J Clin Invest. 2009 Jan; 119(1):47-60.View abstract
55. 免疫球蛋白E抗体可增强通过吸入化学触觉引起的肺部炎症。临床过敏。2009年3月；39（3）：417-25。View abstract
56. Polyclonal and specific antibodies mediate protective immunity against enteric helminth infection. . 2008 Oct 16; 4(4):362-73.View abstract
57. 小鼠肥大细胞胰蛋白酶MMCP-6是在螺旋状螺旋叶藻的慢性阶段自适应和先天免疫之间的关键联系。J免疫。2008年4月1日;180（7）：4885-91。View abstract
58. 在过敏性肺部炎症的发展中，需要在常驻肺细胞中表达的TNF受体相关因子1。J免疫。2008年2月1日；180（3）：1878-85。View abstract
59. Impaired immune response to vaccinia virus inoculated at the site of cutaneous allergic inflammation. J Allergy Clin Immunol. 2007 Dec; 120(6):1382-8.View abstract
60. Skin inflammation in RelB(-/-) mice leads to defective immunity and impaired clearance of vaccinia virus. J Allergy Clin Immunol. 2007 Mar; 119(3):671-9.View abstract
61. The H1 histamine receptor regulates allergic lung responses. J Clin Invest. 2006 Jun; 116(6):1624-32.View abstract
62. The complement component C3 plays a critical role in both Th1 and Th2 responses to antigen. J Allergy Clin Immunol. 2006 Jun; 117(6):1455-61.View abstract
63. TRAF1 regulates Th2 differentiation, allergic inflammation and nuclear localization of the Th2 transcription factor, NIP45. Int Immunol. 2006 Jan; 18(1):101-11.View abstract
64. COX-2抑制增强了Th2免疫反应对表皮敏化的反应。J过敏临床免疫。2005年8月；116（2）：390-6。View abstract
65. Antigen-independent effects of immunoglobulin E. Curr Allergy Asthma Rep. 2005 May; 5(3):186-90.View abstract
66. Cytotoxic T-cells specific for natural IgE peptides downregulate IgE production. Cell Immunol. 2005 Jan; 233(1):11-22.View abstract
67. IgE对肥大细胞的抗原独立作用增强了皮肤中的免疫敏化。诺华找到了Symp。2005;271：15-24;讨论24-38，95-9。View abstract
68. The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen. J Clin Invest. 2004 Aug; 114(3):399-407.View abstract
69. IgE的抗原无关作用增强了皮肤中的免疫敏化。免疫。2004年4月；20（4）：381-92。View abstract
70. Effect of environmental intervention on mouse allergen levels in homes of inner-city Boston children with asthma. Ann Allergy Asthma Immunol. 2004 Apr; 92(4):420-5.View abstract
71. IgE enhances parasite clearance and regulates mast cell responses in mice infected with Trichinella spiralis. J Immunol. 2004 Jan 15; 172(2):1139-45.View abstract
72. Epicutaneous sensitization with superantigen induces allergic skin inflammation. J Allergy Clin Immunol. 2003 Nov; 112(5):981-7.View abstract
73. Targeted inactivation of the IL-4 receptor alpha chain I4R motif promotes allergic airway inflammation. J Exp Med. 2003 Oct 20; 198(8):1189-200.View abstract
74. IL-10 is critical for Th2 responses in a murine model of allergic dermatitis. J Clin Invest. 2003 Oct; 112(7):1058-66.View abstract
75. Management of an anaphylactoid reaction to methotrexate with a stepwise graded challenge. Pediatr Allergy Immunol. 2003 Oct; 14(5):409-11.View abstract
76. Desloratadine inhibits allergen-induced airway inflammation and bronchial hyperresponsiveness and alters T-cell responses in murine models of asthma. J Allergy Clin Immunol. 2003 Jul; 112(1):149-58.View abstract
77. CCR3对于皮肤炎症的鼠模型中的皮肤和气道高反应性至关重要。J Clin Invest。2002年3月；109（5）：621-8。View abstract
78. Mast cells regulate IFN-gamma expression in the skin and circulating IgE levels in allergen-induced skin inflammation. J Allergy Clin Immunol. 2002 Jan; 109(1):106-13.View abstract
79. Giant cell myocarditis in a 12-year-old girl with common variable immunodeficiency. Mayo Clin Proc. 2002 Jan; 77(1):92-6.View abstract
80. Alterations of the X-linked lymphoproliferative disease gene SH2D1A in common variable immunodeficiency syndrome. Blood. 2001 Sep 01; 98(5):1321-5.View abstract
81. IgE regulation and roles in asthma pathogenesis. J Allergy Clin Immunol. 2001 Mar; 107(3):429-40.View abstract
82. An obligate role for T-cell receptor alphabeta+ T cells but not T-cell receptor gammadelta+ T cells, B cells, or CD40/CD40L interactions in a mouse model of atopic dermatitis. J Allergy Clin Immunol. 2001 Feb; 107(2):359-66.View abstract
83. Resolution of bronchial hyperresponsiveness and pulmonary inflammation is associated with IL-3 and tissue leukocyte apoptosis. J Immunol. 2001 Feb 01; 166(3):2033-40.View abstract
84. Regulation of the IgE isotype switch: new insights on cytokine signals and the functions of epsilon germline transcripts. Curr Opin Immunol. 2000 Dec; 12(6):618-23.View abstract
85. 过敏原诱导的小鼠支气管高反应性需要CD40L而不是CD40。AM J呼吸细胞分子生物学。2000年11月；23（5）：646-51。View abstract
86. IgE in asthma and atopy: cellular and molecular connections. J Clin Invest. 1999 Oct; 104(7):829-35.View abstract
87. SLP-76 deficiency impairs signaling via the high-affinity IgE receptor in mast cells. J Clin Invest. 1999 Jun; 103(12):1737-43.View abstract
88. Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis. J Clin Invest. 1999 Apr; 103(8):1103-11.View abstract
89. Position-dependent inhibition of class-switch recombination by PGK-neor cassettes inserted into the immunoglobulin heavy chain constant region locus. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):3000-5.View abstract
90. The X-linked lymphoproliferative-disease gene product SAP regulates signals induced through the co-receptor SLAM. Nature. 1998 Oct 01; 395(6701):462-9.View abstract
91. Molecular and biological characterization of the murine leukotriene B4 receptor expressed on eosinophils. J Exp Med. 1998 Sep 21; 188(6):1063-74.View abstract
92. The expression of murine B cell CD23, in vivo, is regulated by its ligand, IgE. Int Immunol. 1998 Sep; 10(9):1377-84.View abstract
93. A murine model of allergic rhinitis: studies on the role of IgE in pathogenesis and analysis of the eosinophil influx elicited by allergen and eotaxin. J Allergy Clin Immunol. 1998 Jul; 102(1):65-74.View abstract
94. IgE regulates mouse basophil Fc epsilon RI expression in vivo. J Immunol. 1997 Mar 15; 158(6):2517-21.View abstract
95. Normal ranges for lymphocyte subsets in children. J Pediatr. 1997 Mar; 130(3):347-9.View abstract
96. Searching for genes involved in the pathogenesis of primary immunodeficiency diseases: lessons from mouse knockouts. J Clin Immunol. 1997 Mar; 17(2):109-26.View abstract
97. Allergen-induced bronchial hyperreactivity and eosinophilic inflammation occur in the absence of IgE in a mouse model of asthma. Proc Natl Acad Sci U S A. 1997 Feb 18; 94(4):1344-9.View abstract
98. IgE enhances mouse mast cell Fc(epsilon)RI expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions. J Exp Med. 1997 Feb 17; 185(4):663-72.View abstract
99. Mice with a targeted deletion of the IgE gene have increased worm burdens and reduced granulomatous inflammation following primary infection with Schistosoma mansoni. J Immunol. 1997 Jan 01; 158(1):294-300.View abstract
100. eotaxin触发嗜酸性粒细胞选择性趋化性和钙通量通过独特的受体诱导，并在小鼠白介素5的存在下诱导肺嗜酸性粒细胞。摩尔医学。1996年5月；2（3）：334-48。View abstract
101. Active anaphylaxis in IgE-deficient mice. Nature. 1994 Aug 04; 370(6488):367-70.View abstract
102. GD3黑色素瘤疫苗:优越的免疫原性of keyhole limpet hemocyanin conjugate vaccines. Cancer Res. 1994 Jan 01; 54(1):197-203.View abstract
103. Cytokines in clinical cancer therapy. Curr Opin Immunol. 1991 Oct; 3(5):699-705.View abstract
104. 具有双GM2/GD2特异性的人类单克隆抗体来自免疫黑色素瘤患者。Proc Natl Acad Sci U S A. 1990年5月；87（9）：3333-7。View abstract
105. 小鼠单克隆抗体对CD3激活人外周血T细胞的要求。临床免疫疾病。1987年4月；43（1）：48-64。View abstract
106. The T-cell receptor-T3 complex and T-lymphocyte activation. Hum Immunol. 1987 Mar; 18(3):187-204.View abstract
107. A review of the structure and function of the T-cell receptor-T3 complex. Crit Rev Immunol. 1987; 7(2):131-67.View abstract
108. Structural characterization of the TAP molecule: a phosphatidylinositol-linked glycoprotein distinct from the T cell receptor/T3 complex and Thy-1. Cell. 1986 Nov 07; 47(3):365-70.View abstract
109. A T3-like protein complex associated with the antigen receptor on murine T cells. Nature. 1986 Mar 20-26; 320(6059):272-5.View abstract
110. T细胞受体/T3复合物。一年免疫。1986;2：245-53。View abstract
111. Surface antigens of melanomas and melanocytes defined by mouse monoclonal antibodies: specificity analysis and comparison of antigen expression in cultured cells and tissues. Cancer Res. 1985 Sep; 45(9):4401-11.View abstract
112. Purification, preliminary characterization, and immunological comparison of hog lens leucine aminopeptidase (EC 3.4.11.1) with hog kidney and beef lens aminopeptidases. Anal Biochem. 1985 Apr; 146(1):238-45.View abstract
113. Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx. Cell. 1985 Mar; 40(3):583-90.View abstract
114. The T3/T cell receptor complex: antigenic distinction between the two 20-kd T3 (T3-delta and T3-epsilon) subunits. EMBO J. 1985 Feb; 4(2):337-44.View abstract
115. The delta- and epsilon-chains of the human T3/T-cell receptor complex are distinct polypeptides. Nature. 1984 Nov 29-Dec 5; 312(5993):455-8.View abstract
116. Characterization of the two heavy chains of the T3 complex on the surface of human T lymphocytes. J Biol Chem. 1984 Oct 10; 259(19):12039-48.View abstract
117. Comparison of leucine aminopeptidase from human lens, beef lens and kidney, and hog lens and kidney. Exp Eye Res. 1984 Mar; 38(3):217-29.View abstract
118. 克隆的IL-2依赖性T细胞的体内定位。细胞免疫。1983年2月15日；76（1）：69-80。View abstract
119. Further biochemical studies of the human B-cell differentiation antigens B1 and B2. Hybridoma. 1983; 2(1):17-28.View abstract