环状中性粒细胞减少|症状和原因
环状中性粒细胞减少症的症状是什么?
环状中性粒细胞减少症的迹象通常在出生时或之后出现。这种情况的特征是中性粒细胞减少症的复发性发作,持续三到五天。在中性粒细胞减少症的发作中,人体对抗感染可能更困难。所产生的感染的严重程度可能会有所不同,并且通常与中性粒细胞减少本身的严重程度相似。
症状during periods of neutropenia may include:
- 经常性发烧
- 咽喉痛 (咽炎)
- inflammation of the gums (gingivitis)
- 发炎和酸痛(气孔炎)
- infections in the skin and in other areas of the body
循环频率似乎随着年龄的增长而降低,某些患者可能会在30岁时消失。循环中性粒细胞减少症的儿童仅在中性粒细胞减少症中有症状。在其他时候,当它们的中性粒细胞水平正常时,它们不易感染。
What causes cyclic neutropenia?
Cyclic neutropenia is inherited in an autosomal-dominant (non-sex chromosomes) pattern. This means only one copy of the altered gene in each cell is sufficient to cause the condition. In most cases, an affected person inherits the mutation from one affected parent. Other cases result from new mutations in the gene and occur in people with no family history.
环状中性粒细胞减少|Diagnosis & Treatments
如何诊断环状中性粒细胞减少症?
可能会根据标志怀疑诊断症状, including regular fluctuations in the level of neutrophils in the blood. The diagnosis of cyclic neutropenia is often confirmed by blood work.
环状中性粒细胞减少的治疗选择是什么?
环状中性粒细胞减少症的治疗可能包括服用抗生素药物以进行发烧和感染。展出的孩子腹痛need to be carefully evaluated for potentially serious complications.
对于有匹配捐助者的人,一个干细胞移植可能是首选的治疗选择。干细胞移植是对先天性中性粒细胞减少症患者不反应G-CSF或对癌症进行恶性转化的唯一替代疗法。