临床药物基因组学服务

临床药物基因组学服务(CPS)在波士顿欧宝彩票平台儿童医院,通过在做出药物选择的决策时纳入患者的遗传信息,从而使药物更安全,更有效。我们是一项独特的服务;该国仅有少数几个中心之一,这些中心应用遗传学来确定药物反应的变化以改善临床护理。

在选择药物时,处方者(医生,护士从业者,医生的助手)考虑了许多变量,以确定最适合您的药物和剂量。这包括您的诊断,其他医疗状况/个人特征,过敏,以前的药物病史和许多其他临床特征。然而,所有这些类别似乎相似的人对同一药物的反应可能完全不同。有些人经历的副作用可能从轻度到重度;而其他人可能根本没有任何作用。通过确定个人的药物遗传背景,我们可以优化更安全且更有可能工作的药物选择。

临床药物基因组学服务(CPS)致力于选择合适的治疗药物。

这是因为:

  • 人们担心可能的反应,这可能基于家庭或过去的经验
  • 对药物缺乏反应
  • 意外的副作用。

药物反应的性质可以部分解释遗传学。我们基因的差异可以直接影响药物的细分方式以及它们的作用。药物基因组学, is a branch of personalized medicine that focuses on the application of this genetic information to better inform medication choices based on the individual’s “pharmaco”genes that instruct how they will process a medicine, allowing us to better predict whether a person is likely to respond to the medication and whether they are more or less likely to develop side effects.

此外,由于DNA是遗传的,因此药物基因组学测试的结果也可能与相关家庭成员有关。如果检测到临床上的显着结果,则可以考虑这些家庭成员的测试。

药物基因组学

为什么选择波士顿儿童医院的临床药物基因组学服务(CPS)?欧宝彩票平台

CPS团队负责订购、分析、解释,nd counseling associated with pharmacogenomic testing at Boston Children’s Hospital. The available tests include analysis of genes affecting medication breakdown, transport, and response. Results from these tests are analyzed by the CPS team to provide any insight into past medication history and to guide future prescribing decisions to help ensure that medications are chosen and dosed in a manner that is safe and effective as far as possible. When genetic variants of significance are detected, results may suggest that increased monitoring for side effects or dose changes are appropriate for certain medications due to modified medication breakdown. Findings may also suggest the prioritization of specific medications or medication classes based on predicted response. In other instances, total avoidance of particular medications may be recommended due to increased risk of serious adverse drug events. The results are also valuable even when no significant variants are detected, as prescribers can be reassured that therapeutic modification based on genetic factors is not necessary.

我们的患者护理方法是跨学科的方法,其中有专门训练的药剂师和遗传学家协同工作,以提供与药物基因组学有关的最新观点,建议和指导。我们与所有专业的处方者合作,将发现纳入适当的临床决策过程中。我们的期望是,通过找到最适合您的药物和剂量,我们可以减少副作用,增加成功治疗的机会,并帮助您获得更好的健康成果。